The University of Juba was established in 1975 and became operational in 1977 in the then Sudan and from the time of its inception the motto of the University of Juba has been “relevance and excellence.” It is the oldest University among the five (5) public Universities of South Sudan. However, after the cession of South Sudan from Sudan in 2011 and the subsequent years that followed, the administration of the University of Juba has improved and modified the mission, vision, strategic plans, and core values of the University, these new policies were successfully endorsed by the council of the University of Juba on 4th December 2014. Indeed this was the milestone that opened the way for the establishment of new Schools and centers of learning for the student population of this country. Hence, the University of Juba is aiming to increase the student enrollment from 21,000 in 2020 to 60,000 by 2030. Therefore, to realize one of the goals of expanding access to higher education, the administration of the University of Juba took the initiative to establish the School of Medical Laboratory Sciences among others. This was by the resolution of the Deans’ Board No: 07-2020 held on Tuesday 7th July 2020, thereafter, an Interim Dean was appointed to oversee the development of the curriculum and mobilize resources for the establishment of the School by 2021.